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 ・ YBRS  serves as a contract manufacturing organization to provide
    with candidate active pharmaceutical ingredients for uses in research
    and clinical investigations.

 ・ YBRS is committed to develop bio-technologies for production, particularly
    of recombinant active pharmaceutical ingredients.

 ・ YBRS welcomes companies overseas to join in the international co-operation for
   
the development of bio-medical science, technology and market.



Aug.22, 2006.   Establishment of Yokohama BioResearch and Supply Inc.

Apr. 10, 2007.   Basic design of the main laboratory completed          

Jul.   1, 2007.   Start-up laboratory opened in Leading Venture Plaza,YSFP,
           Yokohama

Mar. 27, 2008.  Basic design of the expanced main laboratory completed.

Mar.    . 2008.  Alliances made with Apro Life Science Institute, Inc. Tokushima,
                     Protein Express Inc. Chiba, and AMBiS Corp. Okinawa,
                     respectively for marketing, cell and gene technology and for large
                     scale production.

Dec.    . 2009   Kihara Memorial Yokohama Foundation for the Advancement of Life
                     Sciences started to build a new GMPfacility "Yokohama 
                     Biopharmaceutical  Research and Development Center (YBIRD)" for the
                     technological research on and production of recombinant proteines for
                     clinical trials, and called for its operating company .
                     With competitive application, YBRS was appointed as the managing-
                     operating company.

                         

April    . 2011  In March 2011,the construction for the GMP facility, Yokohama 
                     Biophamaceutical Research and Development Center (YBIRD) was
                     completed, and from April 2011, YBRS started to operate it. 
                   (For details of YBIRD, readers are  requesuted to consult the home page
                    of KIhara Memorial yokohama Foundation for the Advancement of 
                    Life Sciences(www.kihara.or.jp)

  

 



Capital:      130,000,000Yen as of Feb. 28, 2014





1. Contract production of recombinant proteins from already established
    recombinant micro-organisms or cultured mammalian cells. While our most
    familiar organisms are recombinant E.coli and CHO cells, other organisms
    will be considered.

2. Contract production of recombinant proteins from already cloned genes and
    plasmids, and yet recombinant production systems to be established.
    A recombinant system using E.coli suitable for industrial production is in our
    hand and available.

3. Contract researches and consultation  to solve specific problems in the industrial
   production of candidate biopharmaceuticals
.

4. Contract researches for technological R&D including those lead by the
   goverment.




1. For the technological development, small scale production, and purification
    of recombinant proteins for research uses 5 to 90 liter jar fermentors
    in a P2 or a LS2 laboratory.

2. For the preparation of microbial seed stocks and master cell banks using a
   GMP controlled P2 laboratory.

3. For the production and purification of recombinant proteins suitable for
   safety studies and clinical studies. Lines of culture vessels and purification
   instruments are installed in tow separate sets of GMP controlled P2 and
   LS1 laboratories, one with upto a 300 liter jar fermentorfor microbial use,
   and the other with upto 500 liter single use culture vessels for mammalian cell cultures-
   resepectively.

*Facilities are located either in YBIRD or partner's companies, both of which are operated or managed by YBRS.




1. GMP controlling technologies and experiences with international standard for
   the production of active ingredient for investigational new drugs.

2. Molecular biological technologies including cloning genes in plasmid,
   formation of recombinant organisms, and facilities to pursue them.

3. Technologies of cultivation and downstream processing for high quality
   recombinant proteins and facilities to pursue them.



Taimei KASE, President

  After being educated in pharmacology, and having developed his career as a medical researcher and business manager in Sankyo Company, Ltd., and then to steer a whole chemical company in Kishi Kasei Co. Ltd..  He has been steering YBRS in 2014.

Toshiharu MATSUMURA, Ph.D. Executive Director & CRO

  With his backgound in biochemistry, and having enjoyed academic career for twenty years in  Univ., Univ. of Tokyo, Stanford Univ. and others, he joined in Meiji Milk Products Co. Ltd. There he lead a new biopharmaceutical project from its molecular genetic stage to  successful GMP production. Then, he was invited to Roman Industry Co. Ltd, for the production technologies of candidate biopharmaceuticals. In 2007, he joined in YBRS as an adjunct member, and since 2010 he hasbeen leading scientific part of YBRS.

Yasuaki KASE, Licenced Pharmacist, Executive Director & Corporate Adviser

  After being educated in pharmacology, and having developed his career as a medical researcher and business manager for almost twenty years in Shionogi Pharmaceutical Co., he was invited to drive R&D projects in Nichi-Iko (pharmaceutical company), and then to steer a whole pharmaceutical company in Roman Insdutry Co. Ltd. With his rich exeprience and human relationship, he founded YBRS in 2006 and have been steering it since then.

Mitsuo FUJINAMI, MA, Auditor

  Being educated in Keio University Graduate School of Economy, and after having spent his first bussiness career in his family business, he joined in Japan Associated Finance Corporation, which was the first venture capital established in Japan. His capability in accounting business flourished since then, leading him to found a financing company by himself. His contribution in YBRS is not only as an auditor, but is highly appreciated as a financial adviser.



Address: Office:             Yokohama Bio Industry Center,
                                  1-6 Suehiro-cho, Tsurumi-ku,
                                  Yokohama 230-0045

Phone                         +81-(0)45-511-1028 

Fax                            +81-(0)45-306-9594 

E-mail:                      
info@yokohamabio.co.jp
  
Public transportation:    15 min. Public Bus drive from Tsurumi Stn, JR Tsurumi line
Free way access:          Ten min. drive from Namamugi ramp or Shioiri ramp,
                                 Metropolitan-express way